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KMID : 1023120120100010091
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Korean Journal of Aesthetic Society
2012 Volume.10 No. 1 p.91 ~ p.97
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Study on Anti-atopic Effects of Black Ginseng
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Shin Young-Jin
Song Gyu-Yong
Jang Hyun-Hee
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Abstract
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The purpose of this study is to investigate the influence of black ginseng (BG) on induced IL-6, IL-8 and MCP- 1 secretion by house dust mite in THP-1 (human acute monocytic leukemia cell line) and EoL-1 (human eosinophilic leukemic cells) cell lines. The house dust mite (Dermatophagoides pteronissinus, D. pteronissinus ) plays a key role in the pathogenesis of allergic diseases, including atopic dermatitis and asthma. Monocyte chemoattractant protein 1 (MCP-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) play a pivotal role in mediating the infiltration of various cells into the skin of atopic dermatitis. The korean ginseng (radix and leaf) was steamed to 3 hr at 120℃ under high pressure. The contents of benzopyrene which was known as a tumor promoting agent were analysed. Also, the inhibitory effect of BG on the induced IL-6, IL-8 and MCP-1 secretion by D. pteronissinus extract (DpE) in THP-1 and MCP-1 cells was examined. The BG extract (radix and leaf) potently suppressed the elevated production of IL-6 and IL-8 induced by DpE treatment in THP-1 and EoL-1 cells. Among them, the crude saponin fraction of BG leaf exhibited the most potent inhibitory activity. Based on the present results, it can be suggested that the 3 hr steaming at 120℃ under high pressure is the most optimal processing condition and BG may be useful to develop functional food on atopic dermatitis.
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KEYWORD
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Black ginseng, Anti-atopic effect, IL-6, IL-8, MCP-1
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